Coli-Urinal Effervescent Granules 60 gm

Piperazine/Hexamine/Khellin effervescent granules Piperazine (as Piperazine citrate)

What Piperazine/Hexamine/Khellin effervescent granules are used for:

• Piperazine/Hexamine/Khellin effervescent granules are used in the prophylaxis and treatment of chronic or recurrent lower urinary tract infections and asymptomatic bacteriuria.

Do not take Piperazine/Hexamine/Khellin effervescent granules :

• Hypersensitivity to the active substance or to any of the excipients.
• Epilepsy or severe renal impairment and should be given with care to patients with neurological disturbances.
• It should also be avoided or given with extreme caution in patients with hepatic impairment.
• During pregnancy and lactation.
• Severe dehydration, metabolic acidosis, or gout.

Warnings and precautions :

• Use with caution in patients with severe malnutrition and anaemia.

Possible side effects:

• Nausea, vomiting, diarrhoea, abdominal pain, headache, skin rashes, and urticaria occasionally occur.
• Severe neurotoxicity and EEG abnormalities have been reported with symptoms including somnolence, dizziness, nystagmus, muscular incoordination and weakness, ataxia, paraesthesia, myoclonic contractions, choreiform movements, tremor, convulsions, and loss of reflexes.
• Transient visual disturbances such as blurred vision, paralytic strabismus and rarely, cataracts.
• Clonic contractions have occurred but are only likely if neurological abnormalities or renal disease exist.

Allergic reactions occasionally encountered include:

• Skin reactions, arthralgia, fever, oedema and tachycardia.
• Urticaria, photodermatitis, erythema multiforme, purpura, eczematous skin reactions, lacrimation, rhinorrhoea and rarely, broncospasm

Other medicines and Piperazine/Hexamine/Khellin effervescent granules:

• Use of hexamine with sulfonamides may increase the risk of crystalluria
• The use of drugs that alkalinise the urine, including some antacids, potassium citrate, and diuretics such as acetazolamide or the thiazides, should be avoided

How to take Piperazine/Hexamine/Khellin effervescent granules

• 1 tablespoonful dissolved in a half glass of water after meals three times daily.
• Do not exceed the recommended dose of Coli-urinal.

How to store Piperazine/Hexamine/Khellin effervescent granules Store at temperature not exceeding 30°C in a dry place and close tightly after use.

A valid prescription should be available upon delivery